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The discovery and development of selective androgen receptor modulators (SARMs) provides the opportunity to design molecules that are not only orally active, but that target androgen receptors in different tissues to elicit the speci c desired activity [223] The desired activity pro le of novel SARMs is described in Table 185 An ideal SARM for the treatment of primary or secondary male hypogonadism would have the following pro le: orally active, with a pharmacokinetic pro le consistent with once a day administration; capable or incapable of stimulating the prostate, seminal vesicles, and other sex accessory tissues at doses equipotent to those needed to provide increases in muscle mass and strength along with fat-free mass; support bone growth; and maintain/restore erectile function, libido, virilization, and male habitus Unlike testosterone, these SARMs are not substrates for 5 -reductase activity Other activities that are considered undesirable should be diminished or eliminated, such as potential liver toxicity, blood pressure effects, and uid retention,

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hi all, barcode code 128 symbology use modulo 103 for checksum digit. it has 3 subset A , B C, 103,104 and 105 use respectively to calculate checksum .

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N OT E Photo from the National Oceanic and Atmospheric Administration/Department of Commerce (wwwphotolibnoaagov/reef/indexhtml)

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induction of gynecomastia, infertility, and overstimulation of erythropoiesis On the other hand, use of SARMs for selected indications provides the rationale for developing molecules with distinct tissue speci city For example, if the target is bone growth in elderly men with osteopenia or osteoporosis, but with no overt signs of hypogonadism, a more anabolic SARM with clear effects on bone and muscle, but lesser activity on prostate or other sex accessory tissues, would be more desirable The compound 7 -methyl-19-nortestosterone (MENT) has a biopotency per molecule 10 times greater than T [224] and it does not undergo 5 reduction, which may or may not be an advantage for its effects on the prostate It retains, however, its capacity to be aromatized to estradiol [225] It cannot be regarded as a SARM since there is no tissue selectivity based on receptor mechanisms, but it is potentially prostate-sparing The effects of MENT on the prostate are two to three times as potent as those of T, but studies with MENT given in a dose suf cient to sustain gonadotropin suppression and anabolism (1/10 of the amount of T) showed a 50% loss in

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