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Identi cation of a ribavirin-resistant NS5B mutation of hepatitis C virus during ribavirin monotherapy Hepatology 2003, 38, 869 878 34 Mardani, M; Jahromi, M K; Naieni, K H; Zeinali, M The ef cacy of oral ribavirin in the treatment of Crimean-Congo hemorrhagic fever in Iran Clin Infect Dis 2003, 36, 1613 1618 Epub 2003 Jun 1614 35 Huggins, J W Prospects for treatment of viral hemorrhagic fevers with ribavirin, a broadspectrum antiviral drug Rev Infect Dis 1989, 11, S750 761 36 Chong, H T; Kamarulzaman, A; Tan, C T; Goh, K J; Thayaparan, T; et al Treatment of acute Nipah encephalitis with ribavirin Ann Neurol 2001, 49, 810 813 37 Huggins, J W; Hsiang, C M; Cosgriff, T M; Guang, M Y; Smith, J I; et al.

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Acquiring the thread context of any non-current thread presents a challenge for a stop-mode debugger. It is worth examining the solution in a little more detail. The context for the current thread is always available directly from the processor. The context for any non-current thread is stored in its supervisor stack. However, as I mentioned in Section 14.3.2, it is not always straightforward to determine where the registers are placed in the stack frame or, indeed, which register subset has been saved, and in which order the registers were pushed. This will depend on the reason

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Prospective, double-blind, concurrent, placebo-controlled clinical trial of intravenous ribavirin therapy of hemorrhagic fever with renal syndrome J Infect Dis 1991, 164, 1119 1127 38 De Clercq, E Antiviral agents: characteristic activity spectrum depending on the molecular target with which they interact Adv Virus Res 1993, 42, 1 55 39 Cinatl, J; Morgenstern, B; Bauer, G; Chandra, P; Rabenau, H; et al Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus Lancet 2003, 361, 2045 2046 40 Morrey, J D; Smee, D F; Sidwell, R W; Tseng, C Identi cation of active antiviral compounds against a New York isolate of West Nile virus Antiviral Res 2002, 55, 107 116 41 Smee, D F; Bray, M; Huggins, J W Antiviral activity and mode of action studies of ribavirin and mycophenolic acid against orthopoxviruses in vitro Antiviral Chem Chemother.

the switch to privileged mode occurred: the thread s user context type. (I list the TUserContext types in Section 14.3.2.1.) In a multi-session debugger, where non-current threads may be visible, the host debugger needs to be able to identify the context of any thread at any time it must always be able to determine the user context type for a thread. The kernel does not routinely store this information, so the stop-mode debug API installs a scheduler callback to update the thread s context type on every reschedule. The result is stored in the NThread object:

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inline TInt NThread::SetUserContextType()

where K 2 ( ) is the modi ed Bessel function of second kind and order 2 . The correlation model can be chosen according to the properties of the physical phenomenon the sink is interested in. Since we are interested in S, which is also a JGRV, we use a special notation with

The context type value can be used as an index into the user context tables. This will yield a structure that describes the layout of the thread s stack, as shown in Figure 14.8.

corr{S, Si } = s,i = K (ds,i ) =

42 Sheehy, A M; Gaddis, N C; Choi, J D; Malim, M H Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein Nature 2002, 418, 646 650 43 Harris, R S; Petersen-Mahrt, S K; Neuberger, M S RNA editing enzyme APOBEC1 and some of its homologs can act as DNA mutators Mol Cell 2002, 10, 1247 1253 44 Harris, R S; Bishop, K N; Sheehy, A M; Craig, H M; Petersen-Mahrt, S K; et al DNA deamination mediates innate immunity to retroviral infection Cell 2003, 113, 803 809 45 Yu, X; Yu, Y; Liu, B; Luo, K; Kong, W; et al Induction of APOBEC3G ubiquitination and degradation by an HIV-1 Vif-Cul5-SCF complex Science 2003, 302, 1056 1060 Epub 2003 Oct 1016 46 Stopak, K.

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