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EUndefined, // iValue is offset from stack pointer EOffsetFromSp, // iValue is offset from stack top EOffsetFromStackTop, // value = SP + offset ESpPlusOffset, }; public: TUint8 iType; TUint8 iValue; }; enum TArmRegisters { EArmR0 = 0, EArmR1 = 1, EArmR2 = 2, EArmR3 = 3, EArmR4 = 4, EArmR5 = 5, EArmR6 = 6, EArmR7 = 7, EArmR8 = 8, EArmR9 = 9, EArmR10 = 10, EArmR11 = 11, EArmR12 = 12, EArmSp = 13, EArmLr = 14, EArmPc = 15, EArmFlags = 16, EArmDacr = 17, };

(5.8)

58. Migliaccio, G.; Tomassini, J. E.; Carroll, S. S.; Tomei, L.; Altamura, S.; et al. Characterization of resistance to non-obligate chain terminating ribonucleoside analogs which inhibit HCV replication in vitro. J. Biol. Chem. 2003, 8, 8. 59. Mansky, L. M. Mutagenic outcome of combined antiviral drug treatment during human immunode ciency virus type 1 replication. Virology 2003, 307, 116 121. 60. Arnold, J. J.; Vignozzi, M.; Stone, J. K.; Andino, R; Cameron, C. E. Remote-site control of an active site delity checkpoint in a viral RNA-dependent RNA polymerase. J: Biol: Chem. 2005, May 5. (epublication).

The TArmContextElement::iType determines how the register location should be calculated. Figure 14.9 shows an example of a thread context table and its associated thread context state. The algorithm for obtaining a thread context is intended to be run on the host by a stop-mode debugger. Here it is:

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The distortion achieved by using M packets to estimate the event S is given as D(M) = E[(S S(M))2 ] (5.9)

where we use the mean-squared error as the distortion metric. Using (5.5) and (5.6) in (5.7), the estimate Zi of each event information Si can be written as Zi = E[Si Yi ] E[Yi2 ] P (Si + Ni ) 2 + N (5.10)

reg_value GetSavedThreadRegister(<thread>,<reg-id>) { type = READ(thread, EThread_UserContextType) IF ( KernelLock != 0 ) RETURN Kernel Locked IF (thread == CurrentThread) RETURN Register not saved current thread // Select the appropriate context table ContextTable = READ(DDebuggerInfo::iThreadContextTable) ContextTable = READ(ContextTable[Type]) // Get stack pointer and stack top SP = READ(<thread>,EThread_SavedSP) StackTop = READ(<thread>, EThread_SupervisorStack) + READ(<thread>,EThread_SupervisorStackSize)

Flaviviral diseases are widespread in tropical regions and are caused by infections due to viruses such as dengue, yellow fever, Japanese encephalitis, and West Nile. Information that has been obtained from genetic, molecular biological, biochemical, and structural studies has elucidated the key processes involved in the life cycle of aviviruses and identi ed several therapeutic targets. These include viral structural proteins such as the envelope protein and nonstructural proteins such as the viral protease, helicase, RNA polymerase, and methyl transferase. This chapter summarizes the information that is currently available on each of these proteins and the work that is being done to target them using suitable inhibitory compounds.

2 S

// Get the iType and iValue fields for this // register from the thread context table iType = READ( &ContextTable[<reg-id>].iType ) iValue = READ( &ContextTable[<reg-id>].iValue ) // Now handle the cases and calculate the IF ( iType == OFFSET_FROM_SP ) RETURN READ( SP[iValue] ); ELSE IF( iType == OFFSET_FROM_STACK_TOP) RETURN READ( StackTop[-iValue] ); ELSE IF( iType == SP_PLUS_OFFSET) RETURN SP[iValue]; ELSE // Other case currently not used by OS RETURN Register Not Valid } // Read field <offset-tag> from <object> val READ(<object>, <offset-tag>) { offset = OffsetTable[<offset-tag>] pointer = <object> RETURN READ( pointer[offset] ) }

The Flavivirus genus of Flaviviridae numbers approximately seventy identi ed members and includes many potent human pathogens.1 These include yellow fever, dengue, Japanese encephalitis, and West Nile viruses, among others. Flaviviruses are arboviruses transmitted by ticks or mosquitoes. Although successful eradication of aviviral vectors have banished infections from North America, aviviruses pervade many of the tropical regions of the world, causing death, disease, and

(5.11)

Thread context by thread's User Context Type Thread Context Table kernel thread context table context table for threads blocked in Exec::WaitForRequest context table for threads in EXEC call context table for threads causing exception in mode_usr context table for threads preempted due to interrupt in mode_usr context table for threads preempted due to interrupt in mode_svc (Example thread context table) iType R0 EUndefined R1 EOffsetFromSp R2 ESpPlusOffset ... ... R14 EOffsetFromStackTop R15 EOffsetFromStackTop ... iValue R0 offset (N/A) R1 offset R2 offset ... ... R14 offset R15 offset ...

Using (5.11) and (5.8) in (5.9), the distortion function D(M) is found to be [3]

Antiviral Drug Discovery for Emerging Diseases and Bioterrorism Threats. Edited by Paul F. Torrence Copyright # 2005 John Wiley & Sons, Inc.

Note that in some states, the Symbian OS kernel exploits the conventions in the ARM-Thumb procedure call standard and thus not all registers in the thread s context will be saved. Typically, the argument registers (that is, R0 R3) are not saved because the caller throws those registers away so reading the thread context for these registers will return garbage values. This is harmless for user code, and it should be harmless for the debugger too. The debugger, if it has the capability, may choose not to show these registers at all.

6 + 2 2S 2 2 M ( S + N )

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